
Clinical Professor
M_MED-CORE-RHEU
+1 415 476-0738
I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.
Publications
Using the technology acceptance model to assess clinician perceptions and experiences with a rheumatoid arthritis outcomes dashboard: qualitative study.
BMC medical informatics and decision making
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report.
Neurology(R) neuroimmunology & neuroinflammation
Sleep disturbance improves with SARS-COV2 vaccinations in patients with Chronic Inflammatory Disease.
Arthritis care & research
A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination.
Journal of clinical virology plus
Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Reactogenicity of the mRNA SARS-CoV-2 Vaccines Associates with Immunogenicity in Patients with Autoimmune and Inflammatory Disease.
Arthritis care & research
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.
Nature communications
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus.
Science (New York, N.Y.)
Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning.
Frontiers in immunology
ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.
Journal of immunology (Baltimore, Md. : 1950)
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
Annals of internal medicine
POS1255 REACTOGENICITY OF SARS-COV-2 VACCINES IN PATIENTS WITH AUTOIMMUNE AND INFLAMMATORY DISEASE.
Annals of the Rheumatic Diseases
Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.
medRxiv : the preprint server for health sciences
Abstract GS1-08: The MYC oncogene suppresses tumor immune infiltration and function which is reversible with combinatorial immunotherapies.
Cancer research
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
Science signaling
A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression.
Journal of Clinical Oncology
The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.
Journal of graduate medical education
Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.
American journal of physiology. Regulatory, integrative and comparative physiology
Sex- and Corticotropin-releasing Factor Receptor 2-dependent Actions of Urocortin 1 During Colitis.
The FASEB Journal
Local antigen and inflammation in the lung induce the preferential establishment and maintenance of CXCR6 and CD49a-expressing antigen-specific CD8 TRM cells in the lung parenchyma and airways (MUC1P.900).
The Journal of Immunology
Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.
Journal of immunology (Baltimore, Md. : 1950)
A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America
The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Nature immunology
B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950)
IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.
International immunology
MicroRNA function in NK-cell biology.
Immunological reviews
Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.
Nature immunology
Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950)
MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.
Immunity
Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation.
Proceedings of the National Academy of Sciences of the United States of America
CXCR3 expression affects the balance of effector and memory CD8 T cell generation (46.6).
The Journal of Immunology
Type I Interferon produced by infected cells but not plasmacytoid dendritic cells is required for effective CD8 T cell responses and clearance of a viral infection (105.37).
The Journal of Immunology
Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
Proceedings of the National Academy of Sciences of the United States of America
NK1.1+ cells are required for neutrophil recruitment to sites of early viral infection (43.4).
The Journal of Immunology
The tyrosine kinase PYK2 integrates TCR and LFA-1 signaling in CD8 T cells to promote effector versus memory fate (83.21).
The Journal of Immunology
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.
Proceedings of the National Academy of Sciences of the United States of America
Regulation of homeostatic chemokine expression and cell trafficking during immune responses.
Science (New York, N.Y.)
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
Science (New York, N.Y.)
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.
Nature immunology
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection.
Journal of immunology (Baltimore, Md. : 1950)
A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
Nature immunology
A role for perforin in downregulating T-cell responses during chronic viral infection.
Journal of virology
Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.
Journal of virology
Molecular pathways of CTL-mediated cytotoxicity.
Immunological reviews
Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.
Proceedings of the National Academy of Sciences of the United States of America
Bone marrow is a major site of long-term antibody production after acute viral infection.
Journal of virology
Cell-mediated cytotoxicity in perforin-less mice.
International reviews of immunology
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
Journal of virology
Immune function in mice lacking the perforin gene.
Proceedings of the National Academy of Sciences of the United States of America
Molecular basis of organ-specific selection of viral variants during chronic infection.
Journal of virology