Mehrdad Matloubian, MD, PhD

Clinical Professor
Medicine
[email protected]
+1 415 476-0738

I have a general interest in mechanisms of immune mediated diseases and approaches for a better understanding of the molecular bases of such processes. The goal is to provided therapeutic for treatment of autoimmune and inflammatory diseases through a better understanding of the involved pathways.

Publications: 

Using the technology acceptance model to assess clinician perceptions and experiences with a rheumatoid arthritis outcomes dashboard: qualitative study.

BMC medical informatics and decision making

Nasrallah C, Wilson C, Hamblin A, Young C, Jacobsohn L, Nakamura MC, Gross A, Matloubian M, Ashouri J, Yazdany J, Schmajuk G

Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report.

Neurology(R) neuroimmunology & neuroinflammation

Rolfes M, Harroud A, Zorn KC, Tubati A, Omura C, Kurtz K, Matloubian M, Berger A, Chiu CY, Wilson MR, Ramachandran PS

Sleep disturbance improves with SARS-COV2 vaccinations in patients with Chronic Inflammatory Disease.

Arthritis care & research

Pawar N, Taylor KE, Yang M, Deepak P, Kim W, Paley MA, Matloubian M, Carvidi A, Ciorba MA, Demissie E, El-Qunni A, Huang K, Kinnett B, McMorrow LE, Paez D, Poole M, Rose A, Schriefer RE, Kim AHJ, Nakamura M, Katz P, Gensler LS

A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination.

Journal of clinical virology plus

Greene SE, Huang Y, Kim W, Liebeskind MJ, Chandrasekaran V, Liu Z, Deepak P, Paley MA, Lew D, Yang M, Matloubian M, Gensler LS, Nakamura MC, O'Hallaran JA, Presti RM, Whelan SPJ, Buchser WJ, Kim AHJ, Weil GJ

Author Correction: Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.

Nature communications

Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Kok M, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefstr?m J, Matloubian M, Goga A

Reactogenicity of the mRNA SARS-CoV-2 Vaccines Associates with Immunogenicity in Patients with Autoimmune and Inflammatory Disease.

Arthritis care & research

Yang MM, Taylor KE, Paez D, Carividi A, Demissie E, Pawar N, El-Qunni AA, McMorrow LE, Schriefer RE, Huang K, Kinnett B, Klebert M, Haile A, O'Halloran JA, Presti RM, Kim W, Ellebedy AH, Ciorba MA, Paley MA, Deepak P, Kim AHJ, Katz P, Matloubian M, Nakamura M, Gensler LS

Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.

Nature communications

Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A

Su1481: IMPACT OF IMMUNOSUPPRESSIVE THERAPIES ON ANTIBODY DECAY FOLLOWING MRNA VACCINATION TO SARS-COV-2 IN A PROSPECTIVE COHORT OF PATIENTS WITH CHRONIC INFLAMMATORY DISEASES.

Gastroenterology

Parakkal Deepak, Wooseob Kim, Michael Paley, Monica Yang, Samantha Burdess, Alexander B. Carvidi, Emanuel Demissie, Alia A. El-Qunni, Alem Haile, Katherine Huang, Guadalupe Oliva Escudero, Lily E. McMorrow, Diana Paez, Niti Pawar, Dana C. Perantie, Rebecca E. Schriefer, Shannon E. Sides, Mahima Thapa, Maté Gergely, Sewuese E. Akuse, Michael Klebert, Lynne Mitchell, Billy D. Nix, Jonathan Graf, Kimberly E. Taylor, Salim Chahin, Matthew A. Ciorba, Patricia Katz, Mehrdad Matloubian, Jane A. O'Halloran, Rachel M. Presti, Gregory F. Wu, Lianne S. Gensler, Mary C. Nakamura, Ali H. Ellebedy, Alfred H. Kim

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus.

Science (New York, N.Y.)

Perez RK, Gordon MG, Subramaniam M, Kim MC, Hartoularos GC, Targ S, Sun Y, Ogorodnikov A, Bueno R, Lu A, Thompson M, Rappoport N, Dahl A, Lanata CM, Matloubian M, Maliskova L, Kwek SS, Li T, Slyper M, Waldman J, Dionne D, Rozenblatt-Rosen O, Fong L, Dall'Era M, Balliu B, Regev A, Yazdany J, Criswell LA, Zaitlen N, Ye CJ

Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning.

Frontiers in immunology

Liu J, Kumar S, Hong J, Huang ZM, Paez D, Castillo M, Calvo M, Chang HW, Cummins DD, Chung M, Yeroushalmi S, Bartholomew E, Hakimi M, Ye CJ, Bhutani T, Matloubian M, Gensler LS, Liao W

ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.

Journal of immunology (Baltimore, Md. : 1950)

Sin JH, Kashyap S, Acenas D, Cortez JT, Lee J, Marson A, Matloubian M, Waterfield MR

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.

Annals of internal medicine

Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, Demissie EG, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Pawar N, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Akuse S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ

POS1255 REACTOGENICITY OF SARS-COV-2 VACCINES IN PATIENTS WITH AUTOIMMUNE AND INFLAMMATORY DISEASE.

Annals of the Rheumatic Diseases

M. Yang, P. Katz, D. Paez, A. Carvidi, M. Matloubian, M. Nakamura, L. S. Gensler

Abstract GS1-08: The MYC oncogene suppresses tumor immune infiltration and function which is reversible with combinatorial immunotherapies.

Cancer research

Joyce V Lee, Filomena Housley, Christina Yau, Golzar Hemmati, Yibing Zhang, Susan Samson, Carole Baas, Hope Rugo, Mehrdad Matloubian, Andrei Goga

A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression.

Journal of Clinical Oncology

Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, Tasha Lea, Julia Rohrberg, Gregor Krings, Andrei Goga

The Molecular Medicine Investigation Unit: Linking Patient Care and Scientific Inquiry in Physician-Scientist Training.

Journal of graduate medical education

Berger A, Matloubian M, Shah NP, Wachter RM, DeRisi JL, Anderson M

miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.

Cell reports

Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM

Perivascular Fibroblasts of the Developing Spleen Act as LTa1ß2-Dependent Precursors of Both T and B Zone Organizer Cells.

Cell reports

Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA

Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.

American journal of physiology. Regulatory, integrative and comparative physiology

Hasdemir B, Mhaske P, Paruthiyil S, Garnett EA, Heyman MB, Matloubian M, Bhargava A

Sex- and Corticotropin-releasing Factor Receptor 2-dependent Actions of Urocortin 1 During Colitis.

The FASEB Journal

Burcu Hasdemir, Mehrdad Matloubian, Elizabeth A Garnett, Melvin B Heyman, Aditi Bhargava

Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.

Journal of immunology (Baltimore, Md. : 1950)

Mueller J, Matloubian M, Zikherman J

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Proceedings of the National Academy of Sciences of the United States of America

Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A

The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

Nature immunology

Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT

B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Clingan JM, Matloubian M

IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia.

International immunology

Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM

MicroRNA function in NK-cell biology.

Immunological reviews

Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL

Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.

Nature immunology

Gérard A, Khan O, Beemiller P, Oswald E, Hu J, Matloubian M, Krummel MF

Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Clingan JM, Ostrow K, Hosiawa KA, Chen ZJ, Matloubian M

MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells.

Immunity

Steiner DF, Thomas MF, Hu JK, Yang Z, Babiarz JE, Allen CD, Matloubian M, Blelloch R, Ansel KM

Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation.

Proceedings of the National Academy of Sciences of the United States of America

Hu JK, Kagari T, Clingan JM, Matloubian M

CXCR3 expression affects the balance of effector and memory CD8 T cell generation (46.6).

The Journal of Immunology

Joyce Hu, Takashi Kagari, Jonathan Clingan, Mehrdad Matloubian

Type I Interferon produced by infected cells but not plasmacytoid dendritic cells is required for effective CD8 T cell responses and clearance of a viral infection (105.37).

The Journal of Immunology

Jonathan Clingan, Kristin Ostrow, Karoline Hosiawa-Meagher, Zhijian Chen, Richard Locksley, Mehrdad Matloubian

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.

Proceedings of the National Academy of Sciences of the United States of America

Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A

NK1.1+ cells are required for neutrophil recruitment to sites of early viral infection (43.4).

The Journal of Immunology

Karoline A. Hosiawa-Meagher, Jon Clingan, Mehrdad Matloubian

The tyrosine kinase PYK2 integrates TCR and LFA-1 signaling in CD8 T cells to promote effector versus memory fate (83.21).

The Journal of Immunology

Soren Beinke, Mehrdad Matloubian, Joseph Schlessinger, Arthur Weiss

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.

Proceedings of the National Academy of Sciences of the United States of America

Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R

Regulation of homeostatic chemokine expression and cell trafficking during immune responses.

Science (New York, N.Y.)

Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

Nature

Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.

Science (New York, N.Y.)

Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

Nature immunology

Cinamon G, Matloubian M, Lesneski MJ, Xu Y, Low C, Lu T, Proia RL, Cyster JG

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

Nature

Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG

Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.

Journal of immunology (Baltimore, Md. : 1950)

Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG

Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Wu-Hsieh BA, Whitmire JK, de Fries R, Lin JS, Matloubian M, Ahmed R

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.

Nature immunology

Matloubian M, David A, Engel S, Ryan JE, Cyster JG

A role for perforin in downregulating T-cell responses during chronic viral infection.

Journal of virology

Matloubian M, Suresh M, Glass A, Galvan M, Chow K, Whitmire JK, Walsh CM, Clark WR, Ahmed R

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.

Journal of immunology (Baltimore, Md. : 1950)

van der Most RG, Sette A, Oseroff C, Alexander J, Murali-Krishna K, Lau LL, Southwood S, Sidney J, Chesnut RW, Matloubian M, Ahmed R

Antiviral cytotoxic T-cell memory by vaccination with recombinant Listeria monocytogenes.

Journal of virology

Slifka MK, Shen H, Matloubian M, Jensen ER, Miller JF, Ahmed R

Molecular pathways of CTL-mediated cytotoxicity.

Immunological reviews

Clark WR, Walsh CM, Glass AA, Hayashi F, Matloubian M, Ahmed R

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.

Proceedings of the National Academy of Sciences of the United States of America

Shen H, Slifka MK, Matloubian M, Jensen ER, Ahmed R, Miller JF

Cell-mediated cytotoxicity in perforin-less mice.

International reviews of immunology

Clark WR, Walsh CM, Glass AA, Huang MT, Ahmed R, Matloubian M

Immune function in mice lacking the perforin gene.

Proceedings of the National Academy of Sciences of the United States of America

Walsh CM, Matloubian M, Liu CC, Ueda R, Kurahara CG, Christensen JL, Huang MT, Young JD, Ahmed R, Clark WR

Molecular basis of organ-specific selection of viral variants during chronic infection.

Journal of virology

Ahmed R, Hahn CS, Somasundaram T, Villarete L, Matloubian M, Strauss JH